[3H]丙咪嗪结合位点与对照、抑郁和精神分裂症患者中血清素摄取之间缺乏关联。

Lack of association between [3H]imipramine binding sites and uptake of serotonin in control, depressed and schizophrenic patients.

作者信息

Wood P L, Suranyi-Cadotte B E, Nair N P, LaFaille F, Schwartz G

出版信息

Neuropharmacology. 1983 Oct;22(10):1211-4. doi: 10.1016/0028-3908(83)90083-7.

Abstract

Uptake of serotonin and [3H]imipramine binding were studied in parallel in the platelets of control, depressed and schizophrenic patients. In the depressed patient group, uptake of serotonin was consistently reduced while [3H]imipramine binding was only decreased in a number of these patients. In the schizophrenic group, uptake of serotonin was reduced to 62% of control with no changes in [3H]imipramine binding being observed. These data demonstrate a clear dissociation between uptake of serotonin and [3H]imipramine binding sites in human platelets. The possible functional role of these [3H]imipramine binding sites remains to be determined.

摘要

在对照组、抑郁症患者组和精神分裂症患者组的血小板中，对血清素摄取和[3H]丙咪嗪结合进行了平行研究。在抑郁症患者组中，血清素摄取持续降低，而[3H]丙咪嗪结合仅在部分患者中降低。在精神分裂症患者组中，血清素摄取降至对照组的62%，未观察到[3H]丙咪嗪结合有变化。这些数据表明，人血小板中血清素摄取与[3H]丙咪嗪结合位点之间存在明显的分离。这些[3H]丙咪嗪结合位点的可能功能作用仍有待确定。