人白细胞中的1,25 - 二羟维生素D3受体
1,25-dihydroxyvitamin D3 receptors in human leukocytes.
作者信息
Provvedini D M, Tsoukas C D, Deftos L J, Manolagas S C
出版信息
Science. 1983 Sep 16;221(4616):1181-3. doi: 10.1126/science.6310748.
PMID:6310748
Abstract
A 1,25-dihydroxyvitamin D3 receptor macromolecule was detected in peripheral mononuclear leukocytes from normal humans. This macromolecule was found to be present in monocytes but absent from normal resting peripheral B and T lymphocytes. However, it was present in established lines of malignant B, T, and non-B, non-T human lymphocytes, as well as in T and B lymphocytes obtained from normal humans and activated in vitro.
摘要
在正常人外周血单个核白细胞中检测到一种1,25 - 二羟维生素D3受体大分子。发现这种大分子存在于单核细胞中，而正常静息外周B淋巴细胞和T淋巴细胞中不存在。然而，它存在于恶性B淋巴细胞、T淋巴细胞以及非B非T淋巴细胞的人淋巴瘤细胞系中，也存在于从正常人获取并在体外激活的T淋巴细胞和B淋巴细胞中。
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