Gitsch E, Salzer H
Wien Klin Wochenschr. 1983 May 27;95(11):385-8.
Determination of the tissue concentration of hormone receptors in gynaecological malignancies has achieved a great importance over the past few years. In carcinoma of the breast this not only constitutes an excellent prognostic parameter, receptor-positive cases usually having a much better prognosis, but also reliably predicts the response to endocrine treatment: the higher the receptor concentration, the higher the remission incidence under hormonal treatment. With regard to the response to chemotherapeutic treatment the predictive value of receptor determinations is still a matter of dispute. In both carcinoma of the breast and carcinoma of the endometrium there is a good correlation between the degree of differentiation and the concentration of receptors. Since the response to treatment with progestational agents depends on the concentration of progesterone receptors, induction of this receptor by means of antioestrogenic medication can be used therapeutically. In ovarian carcinoma a similar distribution of hormone receptors is found. Whether receptor concentration in ovarian carcinoma is related to prognosis and response to endocrine treatment is still under investigation. It can be assumed that determination of hormone receptor concentrations will become an integral part of the management of gynaecological malignancies.
在过去几年中，测定妇科恶性肿瘤中激素受体的组织浓度已变得极为重要。在乳腺癌中，这不仅是一个出色的预后参数，受体阳性病例通常预后要好得多，而且还能可靠地预测对内分泌治疗的反应：受体浓度越高，激素治疗下的缓解率就越高。关于对化疗治疗的反应，受体测定的预测价值仍存在争议。在乳腺癌和子宫内膜癌中，分化程度与受体浓度之间都存在良好的相关性。由于对孕激素制剂治疗的反应取决于孕激素受体的浓度，因此通过抗雌激素药物诱导这种受体可用于治疗。在卵巢癌中也发现了类似的激素受体分布情况。卵巢癌中的受体浓度是否与预后及对内分泌治疗的反应相关仍在研究中。可以设想，测定激素受体浓度将成为妇科恶性肿瘤治疗的一个组成部分。
