Koroza G S, Kudrin A N
Farmakol Toksikol. 1976 Mar-Apr;39(2):155-9.
The contractility of an isolated rabbit uterus was studied. It was found that when used in low concentrations (1.10(-9)-1.10(-7) g/ml) isoprenaline, while stimulating the beta-adrenoreceptors of the uterus, inhibits its contractions, whereas in high concentrations (1.10(6)-1.10(-5) g/ml) it is capable of intensifying uterine contractions owing to stimulation of the uterine alpha-adrenoreceptors. Dihydroergotoxin (1.10(-6) g/ml), a blocking agent of alpha-adrenoreceptors, averts and eliminates the stimulating effect of isoprenaline on the uterus. Propranolol and netalide, blocking agents of the beta-adrenoreceptors, abolish the already developed depressing action of isoprenaline on the contractile activity of the uterus, but fail to prevent this effect with their preliminary application.
对离体兔子宫的收缩性进行了研究。结果发现，当以低浓度（1×10⁻⁹ - 1×10⁻⁷克/毫升）使用异丙肾上腺素时，在刺激子宫β-肾上腺素能受体的同时，会抑制其收缩，而在高浓度（1×10⁻⁶ - 1×10⁻⁵克/毫升）时，由于刺激子宫α-肾上腺素能受体，它能够增强子宫收缩。α-肾上腺素能受体阻断剂双氢麦角毒素（1×10⁻⁶克/毫升）可避免并消除异丙肾上腺素对子宫的刺激作用。β-肾上腺素能受体阻断剂普萘洛尔和奈他洛尔可消除异丙肾上腺素对子宫收缩活动已产生的抑制作用，但在预先应用时无法预防这种作用。
