Jabłonska S, Orth G, Obalek S, Croissant O, Jarzabek-Chorzelska M, Favre M, Kremsdorf D
Arch Geschwulstforsch. 1983;53(3):207-15.
Epidermodysplasia verruciformis, a model of viral oncogenesis in humans, shows a remarkable similarity to Shope papilloma-carcinoma complex in rabbits. In humans and rabbits, both host, i.e. genetics and immunity, and environmental factors are decisive for neoplastic conversion of benign proliferative lesions. The virus seems to function as an initiation and promotor of carcinomatous transformation. In epidermodysplasia verruciformis, specific virus types are involved in malignant conversion, but a deeply depressed cell mediated immunity is responsible for infection with the potentially oncogenic viruses.
疣状表皮发育不良是人类病毒致癌的一种模型，与兔的肖普乳头瘤 - 癌复合体表现出显著相似性。在人类和兔中，宿主因素（即遗传和免疫）以及环境因素对于良性增殖性病变的肿瘤转化都是决定性的。病毒似乎起着癌性转化的启动和促进作用。在疣状表皮发育不良中，特定的病毒类型参与恶性转化，但细胞介导的免疫力严重低下才导致感染潜在致癌病毒。
