高氯酸盐如何改善骨骼肌纤维中的兴奋-收缩偶联。
How perchlorate improves excitation-contraction coupling in skeletal muscle fibers.
作者信息
Lüttgau H C, Gottschalk G, Kovács L, Fuxreiter M
出版信息
Biophys J. 1983 Aug;43(2):247-9. doi: 10.1016/S0006-3495(83)84346-X.
Abstract
The effect of the "chaotropic" anion, perchlorate, on the activation of contraction has been studied in voltage clamped frog skeletal muscle fibers. It was found that the voltage dependence of either the contractile force or the intramembrane charge movement was shifted towards more negative membrane potentials. The maximum values of force or charge movement attained with large depolarizing pulses did not change significantly. It is concluded that a specific perchlorate effect on the movement of charged particles can explain the potentiating effect of perchlorate anions on contractile force, strengthening the view that these charged particles serve as voltage sensors regulating Ca2+ release from the sarcoplasmic reticulum.
摘要
在电压钳制的青蛙骨骼肌纤维中，研究了“离液序列高的”阴离子高氯酸盐对收缩激活的影响。结果发现，收缩力或膜内电荷移动的电压依赖性向更负的膜电位偏移。大去极化脉冲所达到的力或电荷移动的最大值没有显著变化。得出的结论是，高氯酸盐对带电粒子移动的特定作用可以解释高氯酸根阴离子对收缩力的增强作用，强化了这些带电粒子作为调节肌浆网Ca2+释放的电压传感器的观点。
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Membrane charge moved at contraction thresholds in skeletal muscle fibres.在骨骼肌纤维的收缩阈值处，膜电荷发生移动。
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