Galligan J J, Porreca F, Burks T F
Brain Res. 1983 Jul 25;271(2):354-7. doi: 10.1016/0006-8993(83)90301-3.
Activation of endogenous opioid systems by electroconvulsive shock (ECS) produced naloxone-reversible thermal analgesia (52 degrees C hot plate) 5 min after ECS administration. Although opioid peptides injected intracerebroventricularly have previously been found to inhibit gastrointestinal motility, ECS treatment did not affect gastric emptying, small or large intestinal transit. These results suggest that centrally-mediated opioid analgesia and changes in gastrointestinal motility are initiated through independent mechanisms.
电休克（ECS）激活内源性阿片系统后，在给药5分钟时产生了纳洛酮可逆的热镇痛（52摄氏度热板）效果。尽管先前已发现脑室内注射阿片肽可抑制胃肠蠕动，但ECS治疗并未影响胃排空、小肠或大肠的转运。这些结果表明，中枢介导的阿片镇痛和胃肠蠕动变化是通过独立机制启动的。
