Broccardo M, Improta G, Nargi M, Melchiorri P
Regul Pept. 1982 Jul;4(2):91-6. doi: 10.1016/0167-0115(82)90099-4.
The effects of subcutaneous (s.c.) and intracerebroventricular (i.c.v.) injections of dermorphin on gastric emptying and intestinal transit were studied in rats. Dermorphin injected i.c.v. delayed gastric emptying and this effect was dose-dependent. I.c.v. injections of dermorphin also inhibited intestinal transit but a dose level 5 to 10 times higher than that active on gastric emptying was required. Subcutaneous injections of dermorphin also inhibited gastrointestinal transit but inhibition of the two functions never exceeded 60%. The effect of i.c.v. and s.c. doses of dermorphin was antagonized by a 1 mg . kg-1 dose of naloxone s.c. The data suggest the possibility that dermorphin could affect gastrointestinal transit through an action on central and peripheral opiate receptors.
研究了皮下（s.c.）和脑室内（i.c.v.）注射德莫啡对大鼠胃排空和肠道转运的影响。脑室内注射德莫啡会延迟胃排空，且这种作用呈剂量依赖性。脑室内注射德莫啡也会抑制肠道转运，但所需剂量水平比影响胃排空的剂量高5至10倍。皮下注射德莫啡也会抑制胃肠转运，但对这两种功能的抑制从未超过60%。皮下注射1mg·kg-1剂量的纳洛酮可拮抗脑室内和皮下剂量德莫啡的作用。数据表明，德莫啡可能通过作用于中枢和外周阿片受体来影响胃肠转运。
