Gaillard J M, Kafi S, Justafre J C
Encephale. 1982;8(3):413-34.
In order to reinvestigate the role of brain alpha-adrenergic systems in the regulation of paradoxical sleep (PS), we recorded chronically implanted rats under the effect of various neuroactive substances. The functions describing the evolution of PS during sleep were calculated. The following substances were studied at different doses, alone and in various combinations: clonidine, phenoxybenzamine, chlorpromazine, yohimbine, piperoxane and desipramine. Chlorpromazine, yohimbine, piperoxane and desipramine were also studied after pretreatment with alpha-methylparatyrosine. The results are discussed in terms of the known pharmacological properties of these compounds, and indicate that brain alpha-adrenergic systems, probably mainly noradrenergic systems, are positively involved in the maintenance of PS. However, the activity of these systems is controlled by powerful regulatory mechanisms: inhibitory control of transmitter release at the effector site, collateral inhibition within the locus coeruleus and control of transmitter release at the site of collateral inhibition.
为了重新研究脑α-肾上腺素能系统在异相睡眠（PS）调节中的作用，我们在各种神经活性物质的作用下对长期植入电极的大鼠进行了记录。计算了描述睡眠期间PS演变的各项功能指标。我们研究了以下物质在不同剂量下单独使用以及各种组合使用的情况：可乐定、酚苄明、氯丙嗪、育亨宾、哌罗克生和地昔帕明。在使用α-甲基对酪氨酸预处理后，我们还研究了氯丙嗪、育亨宾、哌罗克生和地昔帕明。根据这些化合物已知的药理特性对结果进行了讨论，结果表明脑α-肾上腺素能系统，可能主要是去甲肾上腺素能系统，积极参与了PS的维持。然而，这些系统的活性受到强大调节机制的控制：效应部位递质释放的抑制性控制、蓝斑内的侧支抑制以及侧支抑制部位递质释放的控制。
