Hutcheon D E, Kantrowitz J, Van Gelder R N, Flynn E
Environ Res. 1983 Oct;32(1):104-10. doi: 10.1016/0013-9351(83)90196-2.
Benzo[a]pyrene (BaP) is a useful indicator of exposure to polycyclic aromatic hydrocarbons (PAHs), airborne carcinogenic compounds. Radioimmunoassay was used to test for plasma BaP differences in 61 subjects divided into three groups based on geographic-demographic locale: urban-industrial, urban-residential, and outer suburban. The results showed that the urban-industrial area participants had a significantly higher mean plasma BaP level than did the outer suburban subjects. The urban-residential subjects did not have a significantly different mean plasma benzo[a]pyrene level from either of the other two groups. Obesity, as measured by Quetelet's index, was found to have a significant correlation with BaP levels. These results indicate that radioimmunoassay of plasma for BaP may be used successfully to judge environmental exposure to PAHs, provided physiological considerations such as obesity are taken into account.
苯并[a]芘（BaP）是多环芳烃（PAHs）暴露的一个有用指标，多环芳烃是空气中的致癌化合物。采用放射免疫分析法对61名受试者的血浆BaP差异进行检测，这些受试者根据地理人口统计学区域分为三组：城市工业区、城市居民区和远郊地区。结果显示，城市工业区参与者的血浆BaP平均水平显著高于远郊地区的受试者。城市居民区受试者的血浆苯并[a]芘平均水平与其他两组相比没有显著差异。通过奎特利指数测量发现，肥胖与BaP水平存在显著相关性。这些结果表明，只要考虑到肥胖等生理因素，血浆BaP的放射免疫分析可成功用于判断环境中PAHs的暴露情况。
