绵羊胎盘催乳素在兔和母羊乳腺中催乳活性的比较测定。

Comparative measurement of the lactogenic activity of ovine placental lactogen in rabbit and ewe mammary gland.

作者信息

Servely J L, Emane M N, Houdebine L M, Djiane J, Delouis C, Kelly P A

出版信息

Gen Comp Endocrinol. 1983 Aug;51(2):255-62. doi: 10.1016/0016-6480(83)90079-5.

Abstract

Ovine placental lactogen is known to bind to prolactin receptors and to initiate milk synthesis in the rabbit mammary gland. However, this hormone exhibited a very low capacity of competing with 125I-labeled human growth hormone for the binding to membranes extracted from ewe mammary gland. Ovine placental lactogen was very efficient in provoking the accumulation of beta-casein mRNA in rabbit mammary explants but was much less active on ewe mammary explants. These data indicate that the placental hormone is not a potent lactogen in the homologous species and that its role in the control of mammary gland development and activity may have been previously overestimated.

摘要

已知绵羊胎盘催乳素可与催乳素受体结合，并启动兔乳腺中的乳汁合成。然而，这种激素与125I标记的人生长激素竞争结合从母羊乳腺提取的膜的能力非常低。绵羊胎盘催乳素在促使兔乳腺外植体中β-酪蛋白mRNA积累方面非常有效，但对母羊乳腺外植体的活性要低得多。这些数据表明，这种胎盘激素在同源物种中并非强效催乳素，其在控制乳腺发育和活性方面的作用可能此前被高估了。