巨细胞病毒感染中免疫球蛋白G和A不同亚类的病毒特异性抗体活性
Virus-specific antibody activity of different subclasses of immunoglobulins G and A in cytomegalovirus infections.
作者信息
Linde G A, Hammarström L, Persson M A, Smith C I, Sundqvist V A, Wahren B
出版信息
Infect Immun. 1983 Oct;42(1):237-44. doi: 10.1128/iai.42.1.237-244.1983.
Abstract
Healthy donors and patients with primary or reactivated cytomegalovirus infections were examined for antiviral antibodies of the immunoglobulin G (IgG) and IgA subclasses. For this purpose, monoclonal antibodies against the four IgG and the two IgA subclasses were used in enzyme-linked immunosorbent assays with cytomegalovirus antigen. IgG1 and IgG3 were the principal anti-cytomegalovirus subclasses in serum samples from healthy donors and patients. IgG1 was higher in reactivated than in primary disease. Cytomegalovirus-specific IgG2 was detected only in serum samples with high total cytomegalovirus IgG. A few patients with high total serum IgG4 also had cytomegalovirus-specific IgG4 antibodies. During convalescence, there was no significant increase in total IgG of any subclass. Both IgA1 and IgA2 antibodies with cytomegalovirus specificity were detected in patients who had cytomegalovirus antibodies of the IgA class.
摘要
对健康供体以及患有原发性或再激活型巨细胞病毒感染的患者进行了免疫球蛋白G（IgG）和IgA亚类抗病毒抗体检测。为此，在针对巨细胞病毒抗原的酶联免疫吸附测定中使用了针对四种IgG和两种IgA亚类的单克隆抗体。IgG1和IgG3是健康供体和患者血清样本中的主要抗巨细胞病毒亚类。再激活型疾病患者的IgG1水平高于原发性疾病患者。仅在总巨细胞病毒IgG水平较高的血清样本中检测到巨细胞病毒特异性IgG2。少数总血清IgG4水平较高的患者也有巨细胞病毒特异性IgG4抗体。在恢复期，任何亚类的总IgG均无显著增加。在具有IgA类巨细胞病毒抗体的患者中检测到了具有巨细胞病毒特异性的IgA1和IgA2抗体。
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