Luck P, Mikhailidis D P, Dashwood M R, Barradas M A, Sever P S, Dandona P, Wakeling A
J Clin Endocrinol Metab. 1983 Nov;57(5):911-4. doi: 10.1210/jcem-57-5-911.
Plasma norepinephrine concentrations in a group of malnourished patients with anorexia nervosa were significantly (P less than 0.002) lower than those in an age- and sex-matched group of normal subjects. Platelet total alpha-adrenoceptor densities of these patients significantly (P less than 0.002) exceeded those of the controls. The increased total alpha-adrenoceptor density was due to an increase in the alpha 2-adrenoceptor receptor subtype, which mediates epinephrine-induced platelet aggregation. Accordingly, the aggregation response of the patients' platelets was significantly (P less than 0.002) enhanced after epinephrine challenge. We suggest that the starvation-induced fall in plasma norepinephrine levels is associated with the up-regulation of platelet alpha-adrenoceptors. This, in turn, accounts for exaggerated epinephrine-induced platelet aggregation in anorexic patients.
一组患有神经性厌食症的营养不良患者的血浆去甲肾上腺素浓度显著低于（P < 0.002）年龄和性别匹配的正常受试者组。这些患者的血小板总α-肾上腺素能受体密度显著高于（P < 0.002）对照组。总α-肾上腺素能受体密度的增加是由于α2-肾上腺素能受体亚型增加所致，该亚型介导肾上腺素诱导的血小板聚集。因此，肾上腺素激发后，患者血小板的聚集反应显著增强（P < 0.002）。我们认为，饥饿诱导的血浆去甲肾上腺素水平下降与血小板α-肾上腺素能受体上调有关。这反过来又解释了厌食症患者中肾上腺素诱导的血小板聚集过度的现象。
