Kennedy J S, Anderson J D
J Pathol. 1983 Sep;141(1):11-5. doi: 10.1002/path.1711410103.
Thirty-five golden hamsters infected with Leishmania donovani were treated with Pentostam and followed up to determine the effect of treatment on the development of secondary amyloidosis. Seventy untreated golden hamsters infected with L. donovani were followed up as controls to determine the pattern of development of secondary amyloidosis. Amyloid developed in all animals treated and untreated. The treatment significantly prolonged the survival time, but did not inhibit the development of renal amyloid in animals shown by biopsy to be free from renal amyloid at the time of treatment. When amyloid was present in kidney at the time of treatment it progressed invariably to renal failure.
对35只感染杜氏利什曼原虫的金黄地鼠用喷他脒进行治疗，并进行随访，以确定治疗对继发性淀粉样变性发展的影响。将70只未治疗的感染杜氏利什曼原虫的金黄地鼠作为对照进行随访，以确定继发性淀粉样变性的发展模式。所有接受治疗和未接受治疗的动物均出现了淀粉样变性。治疗显著延长了存活时间，但在治疗时经活检显示无肾淀粉样变性的动物中，并未抑制肾淀粉样变性的发展。当治疗时肾脏中存在淀粉样变性时，它总是会发展为肾衰竭。
