Novoa C, García P, Rollán E, González J L
Department of Animal Pathology II (Histology and Pathology), Veterinary Faculty, Complutense University of Madrid, Spain.
Histol Histopathol. 1990 Apr;5(2):225-9.
Thirty 10-week-old hamsters were inoculated intraperitoneally with leishmania infantum amastigotes and were serially killed after 15, 30, 45, 60, 75 and 89-90 days. The adrenal glands of each of them were examined by means of light and electron microscopy. The cortex and medulla of the adrenal gland showed a progressive deposition of amyloid, selectively identified by both optical and ultrastructural techniques. It has been suggested that adrenal amyloidosis during visceral leishmaniasis is directly related to a stimulation of the phagocitary mononuclear system due to the persistence of the antigenic stimulation of the parasite. In addition to these deposits, the presence of inflammatory infiltrates containing lymphocytes, plasmocytes and macrophages with leishmanias confirmed the establishment of leishmaniasis. The deposition of the amyloid fibrils finally leads to the partial destruction of the adrenal parenchyma.
30只10周龄的仓鼠经腹腔接种婴儿利什曼原虫无鞭毛体，并在15、30、45、60、75和89 - 90天后依次处死。对每只仓鼠的肾上腺进行光镜和电镜检查。肾上腺皮质和髓质显示淀粉样物质进行性沉积，通过光学和超微结构技术均可选择性识别。有人提出，内脏利什曼病期间的肾上腺淀粉样变性与寄生虫抗原刺激的持续存在导致吞噬单核系统的刺激直接相关。除了这些沉积物外，含有淋巴细胞、浆细胞和带有利什曼原虫的巨噬细胞的炎性浸润的存在证实了利什曼病的发生。淀粉样纤维的沉积最终导致肾上腺实质部分破坏。
