Ness G C
Mol Cell Biochem. 1983;53-54(1-2):299-306. doi: 10.1007/BF00225261.
Within the last few years considerable evidence has accumulated which indicates that changes in HMG-CoA reductase are due primarily, if not solely, to changes in enzyme quantity. These include the changes caused by insulin, glucagon, cholesterol, mevalonolactone, cholestyramine, compactin, cyclic monoterpenes and the diurnal rhythm. Investigations of whether these changes in enzyme quantity primarily represent changes in rates of enzyme synthesis or degradation are just beginning. Regulation of reductase activity by reversible phosphorylation seems unlikely when all the available data are critically examined.
在过去几年中，积累了大量证据表明，HMG - CoA还原酶的变化主要（如果不是唯一的话）是由于酶量的变化。这些变化包括由胰岛素、胰高血糖素、胆固醇、甲羟戊酸内酯、消胆胺、洛伐他汀、环状单萜和昼夜节律引起的变化。关于这些酶量的变化主要是代表酶合成速率还是降解速率的变化的研究才刚刚开始。当对所有现有数据进行严格审查时，通过可逆磷酸化调节还原酶活性似乎不太可能。
