Meissner G
Mol Cell Biochem. 1983;55(1):65-82. doi: 10.1007/BF00229243.
The ion permeability of sarcoplasmic reticulum vesicles from skeletal and heart muscle has been characterized by radioisotope flux, osmotic and membrane potential measurements, and by incorporating vesicles into planar phospholipid bilayers. The sarcoplasmic reticulum membrane is uniquely permeable to various biologically relevant monovalent ions. At least two and possibly three separate passive permeation systems for monovalent ions have been identified: 1) a K+, Na+ channel, 2) an anion channel, and 3) a H+ (OH-) permeable pathway which may or may not be synonymous with the anion channel. A possible physiological function of these monovalent ion permeation systems is to permit rapid movement of K+, Na+, H+ and Cl- across the membrane counter electrogenic Ca2+ fluxes during Ca2+ release and uptake by sarcoplasmic reticulum.
通过放射性同位素通量、渗透压和膜电位测量，以及将囊泡整合到平面磷脂双分子层中，对来自骨骼肌和心肌的肌浆网囊泡的离子通透性进行了表征。肌浆网膜对各种生物学相关的单价离子具有独特的通透性。已鉴定出至少两种且可能三种独立的单价离子被动渗透系统：1）钾离子、钠离子通道，2）阴离子通道，3）氢离子（氢氧根离子）可渗透途径，其可能与阴离子通道同义，也可能不同义。这些单价离子渗透系统的一个可能生理功能是在肌浆网释放和摄取钙离子期间，允许钾离子、钠离子、氢离子和氯离子跨膜快速移动，以对抗电生性钙离子通量。
