紫外线和γ射线照射的疱疹病毒在紫外线照射的CV-1猴细胞中缺乏增强突变。

Lack of enhanced mutation of UV- and gamma-irradiated herpes virus in UV-irradiated CV-1 monkey cells.

作者信息

Takimoto K

出版信息

Mutat Res. 1983 Sep;121(3-4):159-66. doi: 10.1016/0165-7992(83)90197-5.

Abstract

The frequency of forward mutation of unirradiated, UV-irradiated or gamma-irradiated herpes virus was determined after infecting UV-irradiated or unirradiated CV-1 monkey kidney cells, to investigate the correlation between UV-enhanced reactivation (UVER) and mutagenesis. UV-irradiation to cells had no effect on mutation frequency of irradiated virus even in the conditions in which UVER was maximally expressed for the survival of UV-irradiated virus.

摘要

在感染紫外线照射或未照射的CV-1猴肾细胞后，测定未照射、紫外线照射或γ射线照射的疱疹病毒正向突变的频率，以研究紫外线增强复活（UVER）与诱变之间的相关性。即使在紫外线照射的病毒存活时UVER最大程度表达的条件下，对细胞进行紫外线照射对照射病毒的突变频率也没有影响。