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[灌注神经元上渗透压梯度对内向钠通道门控机制的修饰作用]

[Modification of the gating mechanism of incurrent sodium channels by an osmotic pressure gradient on a perfused neuron].

作者信息

Osipchuk Iu V

出版信息

Neirofiziologiia. 1983;15(4):437-9.

PMID:6312344
Abstract

The influence of the osmotic pressure gradient was investigated by the voltage clamp method. It was shown that the osmotic gradient changed both activation and inactivation of the sodium conductivity and decreased the sodium current amplitude. Conductivity of single sodium channels was not affected by the osmotic pressure gradient. It is concluded that the decrease in sodium current amplitude is due to a decrease in the number of open channels.

摘要

通过电压钳法研究了渗透压梯度的影响。结果表明，渗透压梯度改变了钠电导的激活和失活，并降低了钠电流幅度。单个钠通道的电导不受渗透压梯度的影响。得出的结论是，钠电流幅度的降低是由于开放通道数量的减少。

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Cell Mol Neurobiol. 1993 Apr;13(2):183-90. doi: 10.1007/BF00735374.