v-rel的核苷酸序列：网状内皮增生症病毒的癌基因。
Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis virus.
作者信息
Stephens R M, Rice N R, Hiebsch R R, Bose H R, Gilden R V
出版信息
Proc Natl Acad Sci U S A. 1983 Oct;80(20):6229-33. doi: 10.1073/pnas.80.20.6229.
Abstract
The nucleotide sequence of v-rel, the oncogene carried by reticuloendotheliosis virus (REV), has been determined. The defective transforming genome REV arose through the insertion of v-rel (1,415 nucleotides) into the env gene of the helper virus REV-A. The predicted rel protein (503 amino acids) employs the REV-A env initiator and terminates within the p20E region of env. Because there are no natural antisera that detect the REV transforming protein, this nucleotide sequence provides the first step toward its isolation and characterization. The predicted protein is clearly distinct from all other reported transforming proteins but may be very distantly related to members of the src family.
摘要
已确定网状内皮组织增生症病毒（REV）携带的癌基因v-rel的核苷酸序列。缺陷型转化基因组REV是通过将v-rel（1415个核苷酸）插入辅助病毒REV-A的env基因中产生的。预测的rel蛋白（503个氨基酸）利用REV-A env起始密码子，并在env的p20E区域内终止。由于没有能检测REV转化蛋白的天然抗血清，该核苷酸序列为其分离和鉴定迈出了第一步。预测的蛋白明显不同于所有其他已报道的转化蛋白，但可能与src家族成员有非常远的亲缘关系。
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