秋水仙碱对抗利尿激素作用于蛙皮通透性的抑制作用。
Colchicine inhibition of ADH effect on frog skin permeability.
作者信息
Svelto M, Lippe C
出版信息
Experientia. 1978 Mar 15;34(3):360-1. doi: 10.1007/BF01923035.
PMID:631265
Abstract
ADH and AMPc enhance both thiourea unidirectional fluxes in frog skin. This effect is completely abolished by colchicine pretreatment. The ADH increase of thiourea discharge with or without colchicine led us to suppose that colchicine does not directly affect ADH action on outer membrane permeability, but exerts its effects on a site which is limiting for the ADH action on transepithelial permeability.
摘要
抗利尿激素（ADH）和环磷酸腺苷（AMPc）可增强蛙皮中硫脲的单向通量。秋水仙碱预处理可完全消除这种效应。无论有无秋水仙碱，ADH引起的硫脲排出增加使我们推测，秋水仙碱并不直接影响ADH对外膜通透性的作用，而是对一个限制ADH对跨上皮通透性作用的位点发挥其效应。
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