Takaki Y, Kishikawa M, Sekine I, Nishimori I, Hirata M, Namiki H
Acta Pathol Jpn. 1983 Jul;33(4):823-9. doi: 10.1111/j.1440-1827.1983.tb02130.x.
Malignant fibrous histiocytoma (MFH) has become one of the most common malignancies occurring in soft tissue. To our knowledge, the present case is the first of MFH occurring in the endometrium. The uterus removed from a 47-year-old woman demonstrated a large multinodular endometrial lesion with gross invasive foci in the myometrium and the left oviduct. Microscopically, the endometrial tumor and the invasive lesions were composed of dense sheets of markedly pleomorphic cells consisting of fibroblast-like cells, histiocyte-like cells, foamy histiocytes, benign appearing multinucleated giant cells resembling either osteoclasts or Touton giant cells, and bizarre tumor giant cells. Some of the tumor cells showed phagocytic activities. The tumor cells were oriented in a random or haphazard fashion and classical storiform and fascicular patterns were not observed. The tumor was diagnosed as MFH consisting exclusively of so-called pleomorphic pattern. The patient is alive without evidence of disease, months following total hysterectomy and bilateral salpingo-oophorectomy.
恶性纤维组织细胞瘤（MFH）已成为软组织中最常见的恶性肿瘤之一。据我们所知，本病例是首例发生于子宫内膜的MFH。从一名47岁女性切除的子宫显示出一个大的多结节性子宫内膜病变，在肌层和左侧输卵管有明显的浸润灶。显微镜下，子宫内膜肿瘤和浸润性病变由密集的片状明显多形性细胞组成，这些细胞包括成纤维细胞样细胞、组织细胞样细胞、泡沫状组织细胞、外观良性的多核巨细胞（类似破骨细胞或 Touton 巨细胞）以及怪异的肿瘤巨细胞。一些肿瘤细胞显示出吞噬活性。肿瘤细胞呈随机或杂乱排列，未观察到经典的车辐状和束状模式。该肿瘤被诊断为仅由所谓多形性模式组成的MFH。患者在全子宫切除和双侧输卵管卵巢切除术后数月仍存活，无疾病证据。
