Karseladze A I, Zakharova T I, Navarro S, Llombart-Bosch A
Dept. of Pathology, Cancer Research Center, Moscow, Russia.
Eur J Gynaecol Oncol. 2000;21(6):588-90.
A 56-year-old menopausal woman was admitted to hospital because of vaginal spotting of several months duration. The patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy and omentectomy. On divalving, the uterus showed an ulcerated nodule 8 cm in diameter, protruding into the uterine cavity from the posterior wall. Histologically the tumor had a typical morphology of malignant fibrous histiocytoma (MFH). Multinucleated giant cells were strongly positive for CD 68 alpha antichymotripsin and alpha antitrypsin. Mononuclear cells also showed the same immunohistochemical pattern though less intensive than the giant cells. The cells were uniformly negative for S-100 protein, myoD1, myogenin desmin and actin. Electron microscopical investigation disclosed ultrastructural features compatible with the histiocytic nature of the tumor. Thirty-three months later the patient was free of disease.
一名56岁的绝经后女性因持续数月的阴道点滴出血入院。患者接受了全腹子宫切除术、双侧输卵管卵巢切除术和大网膜切除术。打开子宫时，发现一个直径8厘米的溃疡结节，从后壁突入子宫腔。组织学上，肿瘤具有恶性纤维组织细胞瘤（MFH）的典型形态。多核巨细胞对CD 68α抗胰凝乳蛋白酶和α抗胰蛋白酶呈强阳性。单核细胞也显示出相同的免疫组化模式，尽管强度比巨细胞弱。这些细胞对S-100蛋白、肌分化抗原1、生肌调节因子、结蛋白和肌动蛋白均呈阴性。电子显微镜检查发现超微结构特征与肿瘤的组织细胞性质相符。33个月后，患者无疾病迹象。
