Kimura T, Suzuki S, Yoshimizu M
Antiviral Res. 1983 Aug;3(2):103-8. doi: 10.1016/0166-3542(83)90031-1.
The therapeutic efficacy of 9-(2-hydroxyethoxymethyl) guanine (Acyclovir, ACV) was evaluated using Oncorhynchus masou virus (OMV) and chum salmon fry. The fish, which were experimentally infected with OMV, were treated with ACV either orally or by the immersion method. Daily immersion of fish into ACV solution (25 microgram/ml, 30 min/day, 15 times) reduced mortality of the infected fish. Oral administration of the drug (25 microgram/fish per day, 60 times) did not affect survival of the chum salmon. On the contrary, the group administered 5-iodo-2'-deoxyuridine (IUdR) by the oral route showed a higher survival than the ACV-administered group. This suggested that an effective level of ACV was not maintained in fish given the drug by the oral route. Daily immersion of infected fish into ACV solution (25 microgram/ml, 30 min/day, 60 times) considerably suppressed the development of tumors induced by OMV.
使用马苏大马哈鱼病毒（OMV）和大麻哈鱼幼鱼评估了9-（2-羟乙氧甲基）鸟嘌呤（阿昔洛韦，ACV）的治疗效果。将经实验感染OMV的鱼通过口服或浸泡法用ACV进行治疗。每天将鱼浸泡在ACV溶液中（25微克/毫升，每天30分钟，共15次）可降低受感染鱼的死亡率。口服该药物（每天25微克/鱼，共60次）对大麻哈鱼的存活率没有影响。相反，经口服途径给予5-碘-2'-脱氧尿苷（IUdR）的组比给予ACV的组存活率更高。这表明通过口服途径给药的鱼体内未维持有效水平的ACV。每天将受感染的鱼浸泡在ACV溶液中（25微克/毫升，每天30分钟，共60次）可显著抑制由OMV诱导的肿瘤的发展。
