用去甲肾上腺素治疗大鼠会刺激肝脏线粒体中过氧化氢的生成。
Noradrenaline treatment of rats stimulates H2O2 generation in liver mitochondria.
作者信息
Swaroop A, Patole M S, Puranam R S, Ramasarma T
出版信息
Biochem J. 1983 Sep 15;214(3):745-50. doi: 10.1042/bj2140745.
Abstract
Treatment of rats with noradrenaline stimulated H2O2 generation in liver mitochondria using succinate, choline or glycerol 1-phosphate as substrate. The dehydrogenase activity with either succinate or choline as substrate showed no change, whereas that with glycerol 1-phosphate increased. The effect was obtained with noradrenaline, but not with dihydroxyphenylserine. Phenoxybenzamine and yohimbine, but not propranolol, prevented the response to noradrenaline treatment. Phenylephrine could stimulate H2O2 generation, whereas isoprenaline had only a marginal effect. Theophylline treatment slightly decreased the generation of H2O2 in liver mitochondria, but treatment with pargyline, Ro4-1284 and dibutyryl cyclic AMP had little effect. These studies showed that noradrenaline might possibly be acting through the alpha 2-adrenergic system.
摘要
用去甲肾上腺素处理大鼠，以琥珀酸、胆碱或甘油-1-磷酸为底物时，可刺激肝线粒体中过氧化氢的生成。以琥珀酸或胆碱为底物时脱氢酶活性无变化，而以甘油-1-磷酸为底物时脱氢酶活性增加。去甲肾上腺素可产生这种效应，而二羟基苯丝氨酸则不能。酚苄明和育亨宾可阻止对去甲肾上腺素处理的反应，而普萘洛尔则不能。苯肾上腺素可刺激过氧化氢的生成，而异丙肾上腺素只有轻微作用。茶碱处理可使肝线粒体中过氧化氢的生成略有减少，但帕吉林、Ro4-1284和二丁酰环磷腺苷处理的影响不大。这些研究表明，去甲肾上腺素可能是通过α2-肾上腺素能系统起作用的。
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