去甲肾上腺素对肝脏中胆固醇生物合成的刺激性质。
Nature of the stimulation of biogenesis of cholesterol in the liver by noradrenaline.
作者信息
George R, Ramasarma T
出版信息
Biochem J. 1977 Mar 15;162(3):493-9. doi: 10.1042/bj1620493.
Abstract
- Administration of noradrenaline increased the incorporation of [1-14C]acetate into hepatic sterols and the activity of liver microsomal 3-hydroxy-3-methylglutaryl-CoA reductase. 2. The stimulation was observed at short time-intervals with a maximum at 4h and was progressive with increasing concentrations of noradrenaline. 3. Protein synthesis de novo was a necessary factor for the effect. 4. The stimulatory effect was not mediated through the adrenergic receptors, but appears to involve a direct action of the hormone within the hepatocyte.
摘要
- 去甲肾上腺素的给药增加了[1-14C]乙酸盐掺入肝脏甾醇中的量以及肝脏微粒体3-羟基-3-甲基戊二酰辅酶A还原酶的活性。2. 在短时间间隔内观察到这种刺激作用，4小时时达到最大值，并且随着去甲肾上腺素浓度的增加而逐渐增强。3. 从头合成蛋白质是产生该效应的必要因素。4. 这种刺激作用不是通过肾上腺素能受体介导的，而是似乎涉及该激素在肝细胞内的直接作用。
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