在离体灌流的大鼠肝脏中，促胰液素使环磷酸腺苷（cAMP）升高但不引起糖原分解，而肾上腺素可抑制这一过程。

A rise in cyclic AMP with a lack of glycogenolysis by secretin in the isolated perfused rat liver and its inhibition by epinephrine.

作者信息

Yamatani K, Sato N, Takahashi K, Hara M, Sasaki H

出版信息

Biochem Biophys Res Commun. 1983 Sep 15;115(2):743-8. doi: 10.1016/s0006-291x(83)80207-1.

Abstract

The effects of secretin on glucose output and cyclic AMP from the isolated perfused rat liver were investigated. Secretin 0.1 U/ml increased cyclic AMP in the effluent without an increase in glucose output. Glucose output induced by epinephrine 10(-8)M was not affected by secretin 0.1 U/ml administered simultaneously, whereas the increase in cyclic AMP produced by secretin 0.1 U/ml was inhibited by epinephrine 10(-8)M. The increase in cyclic AMP produced by glucagon 10(-10)M was not affected by epinephrine 10(-8)M. These results suggest that secretin does not affect glycogenolysis in the liver and secretin activates adenylate cyclase through a different receptor from glucagon in the liver.

摘要

研究了促胰液素对离体灌注大鼠肝脏葡萄糖输出和环磷酸腺苷（cAMP）的影响。0.1 U/ml的促胰液素可使流出液中的cAMP增加，但葡萄糖输出未增加。10⁻⁸M肾上腺素诱导的葡萄糖输出不受同时给予的0.1 U/ml促胰液素的影响，而0.1 U/ml促胰液素产生的cAMP增加受到10⁻⁸M肾上腺素的抑制。10⁻¹⁰M胰高血糖素产生的cAMP增加不受10⁻⁸M肾上腺素的影响。这些结果表明，促胰液素不影响肝脏中的糖原分解，且促胰液素通过与肝脏中胰高血糖素不同的受体激活腺苷酸环化酶。