Peripheral adrenoceptors after sino-aortic denervation.

The effect of bilateral sino-aortic denervation on cardiac and renal cortical alpha- and beta-adrenoceptor concentrations was studied in rats by radioligand binding experiments using [3H]-prazosin (alpha 1), [3H]-yohimbine (alpha 2) and [125I]-iodocyanopindolol (beta). Cardiac alpha 1- and beta-adrenoceptor concentrations were not altered by sino-aortic denervation. There was a significant increase in beta-adrenoceptor concentration in the renal cortex of sino-aortic denervated rats compared to sham-operated controls.