Woodcock E A, Morris M J, McLeod J K, Johnston C I
J Recept Res. 1985;5(2-3):133-46. doi: 10.3109/10799898509041875.
The effect of unilateral surgical renal denervation on adrenergic receptors in rat kidney was investigated. Denervation was performed by mechanically stripping the nerves from the renal artery and then painting with phenol. This procedure resulted in a decrease in norepinephrine content to less than 10% of the contralateral kidney. The concentrations of alpha 1-, alpha 2-, beta 1- and beta 2-adrenergic receptors were measured in both kidneys of rats 1 week following left renal denervation. Alpha 1-receptor concentrations increased in the denervated left kidneys relative to the intact right kidneys. Alpha 2-, beta 1- and beta 2-receptor concentrations were not different between left and right kidneys. These results indicate that the different classes of adrenergic receptor in the kidney are differentially regulated by agonist stimulation.
研究了单侧手术肾去神经支配对大鼠肾脏肾上腺素能受体的影响。通过机械剥离肾动脉神经然后涂抹苯酚来进行去神经支配。该操作导致去神经侧肾脏去甲肾上腺素含量降至对侧肾脏的10%以下。在左肾去神经支配1周后，测量大鼠双侧肾脏中α1、α2、β1和β2肾上腺素能受体的浓度。相对于完整的右肾，去神经支配的左肾中α1受体浓度增加。左肾和右肾之间α2、β1和β2受体浓度没有差异。这些结果表明，肾脏中不同类型的肾上腺素能受体受激动剂刺激的调节方式不同。
