苯二氮䓬受体：戊巴比妥对1型受体的优先刺激作用。
Benzodiazepine receptors: preferential stimulation of Type 1 receptors by pentobarbital.
作者信息
Niehoff D L, Mashal R D, Kuhar M J
出版信息
Eur J Pharmacol. 1983 Aug 19;92(1-2):131-4. doi: 10.1016/0014-2999(83)90118-8.
PMID:6313382
Abstract
The binding of [3H]flunitrazepam (FLU) to Type 1 and Type 2 benzodiazepine receptors in rat cerebellum and cerebral cortex was differentiated by the addition of 200 nM CL218,872 which preferentially displaces [3H]FLU from Type 1 receptors. Type 1 but not Type 2 receptor binding was significantly stimulated by 1 mM sodium pentobarbital.
摘要
通过添加200 nM CL218,872来区分[3H]氟硝西泮（FLU）与大鼠小脑和大脑皮层中1型和2型苯二氮䓬受体的结合，CL218,872优先从1型受体置换[3H]FLU。1 mM戊巴比妥钠显著刺激1型而非2型受体结合。
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