Peralta O C, Barr R J, Romansky S G
J Cutan Pathol. 1983 Oct;10(5):350-8. doi: 10.1111/j.1600-0560.1983.tb00338.x.
A case of mixed carcinoma in situ, of the skin, is presented. The lesion, located on the right temple of a 71-year-old man, showed histologic features of Bowen's disease and extramammary Paget's disease. This case suggests that Bowen's disease and extramammary Paget's disease may arise from pluripotential adnexal epithelium capable of keratinocytic and glandular differentiation. Utilization of the peroxidase-antiperoxidase technique for demonstrating carcino-embryonic antigen was performed in order to identify the component interpreted as extramammary Paget's disease. This procedure is apparently more sensitive than the commonly employed histochemical stains for demonstrating glandular differentiation.
本文报告一例皮肤原位混合癌病例。该病变位于一名71岁男性的右颞部，具有鲍恩病和乳腺外佩吉特病的组织学特征。该病例提示，鲍恩病和乳腺外佩吉特病可能起源于能够进行角质形成细胞和腺性分化的多能性附属上皮。为了识别被解释为乳腺外佩吉特病的成分，采用了过氧化物酶-抗过氧化物酶技术来显示癌胚抗原。该方法在显示腺性分化方面显然比常用的组织化学染色更敏感。
