Tada H, Hatoko M, Muramatsu T, Shirai T
Department of Dermatology, Nara Medical University, Kashihara, Japan.
J Dermatol. 1996 Feb;23(2):104-10. doi: 10.1111/j.1346-8138.1996.tb03979.x.
In this study, we investigated the expression of E-cadherin in 31 cases of human skin carcinoma including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Paget's disease, Bowen's disease (invasive type), and trichilemmal carcinoma, by immunohistochemical staining using a monoclonal antibody specific for E-cadherin. Similar to the E-cadherin expression in normal epidermis, E-cadherin was strongly expressed in all samples of BCC on the cell borders, whereas marked decrease or loss of E-cadherin expression was found in the tumor cells of SCC, Paget's disease, and Bowen's disease (invasive type). On the other hand, E-cadherin expression of trichilemmal carcinoma was slightly reduced. Considering the clinical and histological features of these skin carcinoma, the reduction of E-cadherin expression is considered to be associated with the invasion and metastasis of human skin carcinoma.
在本研究中，我们使用针对E-钙黏蛋白的单克隆抗体，通过免疫组织化学染色法，调查了31例人类皮肤癌（包括基底细胞癌、鳞状细胞癌、佩吉特病、鲍温病（浸润型）和毛鞘癌）中E-钙黏蛋白的表达情况。与正常表皮中的E-钙黏蛋白表达情况相似，E-钙黏蛋白在所有基底细胞癌样本的细胞边界处均呈强表达，而在鳞状细胞癌、佩吉特病和鲍温病（浸润型）的肿瘤细胞中，E-钙黏蛋白表达明显减少或缺失。另一方面，毛鞘癌的E-钙黏蛋白表达略有降低。考虑到这些皮肤癌的临床和组织学特征，E-钙黏蛋白表达的降低被认为与人类皮肤癌的侵袭和转移有关。
