Meiklejohn G
J Infect Dis. 1983 Nov;148(5):775-84. doi: 10.1093/infdis/148.5.775.
Surveillance of febrile respiratory diseases at Lowry Air Force Base, Denver, has been maintained from 1952 to 1982 with laboratory confirmation of diagnosis. Unvaccinated recruit populations were extremely vulnerable to explosive outbreaks of influenza A. Ten controlled trials demonstrated the protective efficacy of inactivated vaccines. Recent military vaccines have raised the hemagglutination-inhibiting antibody levels of most persons into the "protective" range. Despite repeated introduction of influenza viruses onto the base, when all personnel were vaccinated the impact of influenza was reduced to an insignificant level except in one year of antigenic shift (1968) and one of major antigenic drift (1972). Adenovirus disease has been virtually eliminated since live oral types 4 and 7 vaccines have been given to incoming recruits. Rubella and rubeola have disappeared since seronegative recruits have received vaccine. Overall rates of febrile respiratory diseases have been greatly reduced.
1952年至1982年期间，丹佛洛瑞空军基地一直对发热性呼吸道疾病进行监测，并通过实验室确诊。未接种疫苗的新兵群体极易爆发甲型流感。十项对照试验证明了灭活疫苗的保护效力。近期的军事疫苗已将大多数人的血凝抑制抗体水平提高到了“保护”范围。尽管流感病毒多次传入基地，但当所有人员都接种疫苗后，流感的影响降至微不足道的水平，只有在抗原转变的一年（1968年）和主要抗原漂移的一年（1972年）除外。自从给新兵接种4型和7型口服活疫苗后，腺病毒疾病实际上已被消除。自从血清阴性的新兵接种疫苗后，风疹和麻疹已经消失。发热性呼吸道疾病的总体发病率已大幅降低。
