产气荚膜梭菌对β-内酰胺类抗生素的耐药性由单一必需青霉素结合蛋白的亲和力降低介导。
Resistance of Clostridium perfringens to beta-lactam antibiotics mediated by a decreased affinity of a single essential penicillin-binding protein.
作者信息
Williamson R
出版信息
J Gen Microbiol. 1983 Aug;129(8):2339-42. doi: 10.1099/00221287-129-8-2339.
PMID:6313857
Abstract
Benzylpenicillin-resistant mutants of Clostridium perfringens have been isolated by in vitro selection. The sole mechanism of resistance was a decreased affinity of the highest molecular weight penicillin-binding protein (PBP1) for the antibiotic.
摘要
通过体外筛选分离出了产气荚膜梭菌的耐苄青霉素突变体。耐药的唯一机制是分子量最大的青霉素结合蛋白（PBP1）对抗生素的亲和力降低。
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