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产气荚膜梭菌对β-内酰胺类抗生素的耐药性由单一必需青霉素结合蛋白的亲和力降低介导。

Resistance of Clostridium perfringens to beta-lactam antibiotics mediated by a decreased affinity of a single essential penicillin-binding protein.

作者信息

Williamson R

出版信息

J Gen Microbiol. 1983 Aug;129(8):2339-42. doi: 10.1099/00221287-129-8-2339.

DOI:10.1099/00221287-129-8-2339
PMID:6313857
Abstract

Benzylpenicillin-resistant mutants of Clostridium perfringens have been isolated by in vitro selection. The sole mechanism of resistance was a decreased affinity of the highest molecular weight penicillin-binding protein (PBP1) for the antibiotic.

摘要

通过体外筛选分离出了产气荚膜梭菌的耐苄青霉素突变体。耐药的唯一机制是分子量最大的青霉素结合蛋白（PBP1）对抗生素的亲和力降低。

相似文献

1
Resistance of Clostridium perfringens to beta-lactam antibiotics mediated by a decreased affinity of a single essential penicillin-binding protein.产气荚膜梭菌对β-内酰胺类抗生素的耐药性由单一必需青霉素结合蛋白的亲和力降低介导。
J Gen Microbiol. 1983 Aug;129(8):2339-42. doi: 10.1099/00221287-129-8-2339.
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Benzylpenicillin-induced filament formation of Clostridium perfringens.苄青霉素诱导产气荚膜梭菌形成丝状体。
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Penicillin-binding proteins in Clostridium perfringens.产气荚膜梭菌中的青霉素结合蛋白。
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Studies on the mechanism of intrinsic resistance to beta-lactam antibiotics in group D streptococci.D组链球菌对β-内酰胺类抗生素固有耐药机制的研究。
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Penicillin-binding proteins and the future of beta-lactam antibiotics. The Seventh Fleming Lecture.青霉素结合蛋白与β-内酰胺类抗生素的未来。第七届弗莱明讲座。
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[Penicillin-resistant mechanisms of Streptococcus pneumoniae].[肺炎链球菌的青霉素耐药机制]
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One or two low affinity penicillin-binding proteins may be responsible for the range of susceptibility of Enterococcus faecium to benzylpenicillin.一两种低亲和力青霉素结合蛋白可能是屎肠球菌对苄青霉素敏感性差异的原因。
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Shifting of the penicillin binding proteins that are the target for inhibition by beta-lactams as a likely mechanism of resistance to antibiotics during therapy.青霉素结合蛋白的改变作为治疗期间对抗生素耐药的一种可能机制，而青霉素结合蛋白是β-内酰胺类药物的抑制靶点。
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Anaerobic bacteria and beta-lactam antibiotics.厌氧菌与β-内酰胺类抗生素
Scand J Infect Dis Suppl. 1984;42:72-82.

引用本文的文献

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Vet Res Commun. 2009 Dec;33(8):1031-7. doi: 10.1007/s11259-009-9306-4.
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beta-Lactamases in laboratory and clinical resistance.实验室及临床耐药中的β-内酰胺酶
Clin Microbiol Rev. 1995 Oct;8(4):557-84. doi: 10.1128/CMR.8.4.557.
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Modification of penicillin-binding proteins as mechanisms of beta-lactam resistance.青霉素结合蛋白的修饰作为β-内酰胺耐药机制
Antimicrob Agents Chemother. 1986 Jul;30(1):1-5. doi: 10.1128/AAC.30.1.1.
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Microbiological investigation of cephalosporins.头孢菌素的微生物学研究。
Drugs. 1987;34 Suppl 2:23-43. doi: 10.2165/00003495-198700342-00005.
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Molecular genetics and pathogenesis of Clostridium perfringens.产气荚膜梭菌的分子遗传学与发病机制
Microbiol Rev. 1991 Dec;55(4):621-48. doi: 10.1128/mr.55.4.621-648.1991.
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Susceptibility testing of anaerobic bacteria: myth, magic, or method?厌氧菌的药敏试验：神话、魔法还是方法？
Clin Microbiol Rev. 1991 Oct;4(4):470-84. doi: 10.1128/CMR.4.4.470.