血浆中肝素辅因子活性及抗凝血酶III浓度与年龄和性别的关系。

Heparin cofactor activity and antithrombin III concentration in plasma related to age and sex.

作者信息

Odegärd O R, Fagerhol M K, Lie M

出版信息

Scand J Haematol. 1976 Oct;17(4):258-62. doi: 10.1111/j.1600-0609.1976.tb01183.x.

DOI:10.1111/j.1600-0609.1976.tb01183.x

Abstract

Heparin cofactor activity and antithrombin III (At-III) concentration were measured in plasma from 219 healthy men and 177 women. Narrow ranges for heparin cofactor activity and At-III concentration were found. The standard deviation for heparin cofactor activity in men and women was 8.6 and 10.1, respectively, for At-III concentration 10.4 and 12.5. In men, mean heparin cofactor activity and mean At-III concentration decreased significantly with increasing age. In women, mean heparin cofactor activity and mean At-III concentration tended to be lower in fertile age. Hereditary At-III deficiency was detected in one individual.

摘要

对219名健康男性和177名健康女性的血浆进行了肝素辅因子活性和抗凝血酶III（At-III）浓度的测定。发现肝素辅因子活性和At-III浓度的范围较窄。男性和女性肝素辅因子活性的标准差分别为8.6和10.1，At-III浓度的标准差分别为10.4和12.5。在男性中，肝素辅因子活性均值和At-III浓度均值随年龄增长而显著降低。在女性中，育龄期的肝素辅因子活性均值和At-III浓度均值往往较低。在一名个体中检测到遗传性At-III缺乏症。