Hesse R, Tritschler W, Castelfranchi G, Bablok W
Blut. 1981 Apr;42(4):227-34. doi: 10.1007/BF00996752.
A new kinetic assay for antithrombin III (heparin-cofactor) in plasma was used to determine reference values. Ranges of 10--15 IU/ml at 25 degrees C and 20--29 IU/ml at 37 degrees C were found for a reference population of 219 men and 204 women 15--93 years of age. There was no evidence that these values vary with age or sex, nor was there any difference between pre- and postprandial antithrombin activities, or between smokers' and non-smokers' values. None of the illnesses present in the reference population nor any related drug therapy affected the antithrombin III level, and there was no statistically significant difference between the values for women taking oral contraceptives and those who did not. However, this latter observation does not preclude the possibility of individual variation.
采用一种新的血浆抗凝血酶III（肝素辅因子）动力学测定法来确定参考值。在15至93岁的219名男性和204名女性参考人群中，发现25摄氏度时的参考值范围为10 - 15国际单位/毫升，37摄氏度时为20 - 29国际单位/毫升。没有证据表明这些值随年龄或性别而变化，餐后抗凝血酶活性在餐前和餐后之间也没有差异，吸烟者和非吸烟者的值之间也没有差异。参考人群中存在的任何疾病或任何相关药物治疗均未影响抗凝血酶III水平，服用口服避孕药的女性和未服用口服避孕药的女性的值之间也没有统计学上的显著差异。然而，后一种观察结果并不排除个体差异的可能性。
