Gammon D, Casida J E
Neurosci Lett. 1983 Sep 30;40(2):163-8. doi: 10.1016/0304-3940(83)90296-3.
Deltamethrin and three insecticidal cyano analogs causing the Type II pyrethroid syndrome increased the input resistance of crayfish claw opener muscle fibers bathed in gamma-aminobutyric acid (GABA). In contrast, two non-toxic stereoisomers and three insecticidal pyrethroids causing the Type I syndrome were inactive. Known GABA antagonists including picrotoxinin (PTX) induced an effect similar to, although quicker than, that caused by the active pyrethroids. Two benzodiazepines reduced the potency of PTX and deltamethrin. Cyanophenoxybenzyl pyrethroids therefore appear to act on the GABA receptor-ionophore complex.
溴氰菊酯和三种导致II型拟除虫菊酯综合征的杀虫氰类似物增加了浸泡在γ-氨基丁酸（GABA）中的小龙虾螯 opener 肌纤维的输入电阻。相比之下，两种无毒立体异构体和三种导致I型综合征的杀虫拟除虫菊酯则无活性。已知的GABA拮抗剂，包括印防己毒素（PTX），产生了与活性拟除虫菊酯相似的效果，尽管速度更快。两种苯二氮卓类药物降低了PTX和溴氰菊酯的效力。因此，氰基苯氧基苄基拟除虫菊酯似乎作用于GABA受体-离子载体复合物。
