• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Direct stimulation of beta 2-adrenergic receptors in rat anterior pituitary induces the release of adrenocorticotropin in vivo.

作者信息

Mezey E, Reisine T D, Palkovits M, Brownstein M J, Axelrod J

出版信息

Proc Natl Acad Sci U S A. 1983 Nov;80(21):6728-31. doi: 10.1073/pnas.80.21.6728.

DOI:10.1073/pnas.80.21.6728
PMID:6314339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC391244/
Abstract

Previous work in our laboratory has shown that stimulation of beta 2-adrenergic receptors on mouse anterior pituitary tumor cells causes the secretion of immunoreactive adrenocorticotropin (ACTH). The present study was designed to test the hypothesis that catecholamines can cause the release of ACTH in vivo by the direct stimulation of beta 2-adrenergic receptors in the rat anterior pituitary. Systemic administration of a beta-adrenergic receptor agonist (-)-isoproterenol resulted in an increase in plasma ACTH levels in intact animals and in rats with transected pituitary stalks. This effect could be blocked by the beta-adrenergic receptor antagonist, propranolol, but not by the specific beta 1-adrenergic receptor antagonist, practolol. Salmefamol, a beta 2-adrenergic receptor agonist also elevated plasma ACTH levels in stalk-sectioned animals. Dexamethasone, a glucocorticoid that inhibits the synthesis and release of ACTH from the anterior pituitary but not the intermediate lobe, prevented the elevation of ACTH secretion by (-)-isoproterenol in stalk-transected rats. These data indicate that beta 2-adrenergic receptors are present on anterior pituitary cells and suggest that catecholamines can directly stimulate ACTH secretion.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/391244/e6d36cb4e807/pnas00647-0306-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/391244/ffd8769682e0/pnas00647-0305-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/391244/e6d36cb4e807/pnas00647-0306-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/391244/ffd8769682e0/pnas00647-0305-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/391244/e6d36cb4e807/pnas00647-0306-a.jpg

相似文献

1
Direct stimulation of beta 2-adrenergic receptors in rat anterior pituitary induces the release of adrenocorticotropin in vivo.
Proc Natl Acad Sci U S A. 1983 Nov;80(21):6728-31. doi: 10.1073/pnas.80.21.6728.
2
Beta-adrenergic mechanism of insulin-induced adrenocorticotropin release from the anterior pituitary.
Science. 1984 Nov 30;226(4678):1085-7. doi: 10.1126/science.6093262.
3
Activation of beta 2-adrenergic receptors on mouse anterior pituitary tumor cells increases cyclic adenosine 3':5'-monophosphate synthesis and adrenocorticotropin release.小鼠垂体前叶肿瘤细胞上β2-肾上腺素能受体的激活增加环磷酸腺苷的合成并促进促肾上腺皮质激素释放。
J Neurosci. 1983 Apr;3(4):725-32. doi: 10.1523/JNEUROSCI.03-04-00725.1983.
4
Interleukin 1 prevents loss of corticotropic responsiveness to beta-adrenergic stimulation in vitro.白细胞介素1可防止体外促肾上腺皮质激素对β-肾上腺素能刺激的反应性丧失。
Proc Natl Acad Sci U S A. 1988 Aug;85(15):5556-60. doi: 10.1073/pnas.85.15.5556.
5
Desensitization of beta adrenergic receptors linked to adrenocorticotropin secretion.与促肾上腺皮质激素分泌相关的β肾上腺素能受体脱敏。
J Pharmacol Exp Ther. 1983 Oct;227(1):107-14.
6
Desensitization of beta 2-adrenergic receptors and adrenocorticotropin release.
Biochem Biophys Res Commun. 1983 Feb 28;111(1):112-9. doi: 10.1016/s0006-291x(83)80124-7.
7
Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines.大鼠中胰岛素诱导的低血糖刺激促肾上腺皮质激素分泌的个体发生：儿茶酚胺的作用
Endocrinology. 1992 Dec;131(6):2763-8. doi: 10.1210/endo.131.6.1359963.
8
Multiple factors involved in the control of ACTH and alpha-MSH secretion.促肾上腺皮质激素（ACTH）和α-促黑素（α-MSH）分泌的调控涉及多种因素。
J Steroid Biochem. 1983 Jul;19(1B):439-45. doi: 10.1016/0022-4731(83)90201-7.
9
Parallel stimulation of ACTH, beta-LPH + beta-endorphin and alpha-MSH release by alpha-adrenergic agents in rat anterior pituitary cells in culture.α-肾上腺素能药物对培养的大鼠垂体前叶细胞促肾上腺皮质激素、β-促脂素+β-内啡肽和α-黑素细胞刺激素释放的平行刺激作用
Mol Cell Endocrinol. 1981 Jun;22(3):295-303. doi: 10.1016/0303-7207(81)90038-1.
10
Beta-adrenergic receptors are involved in histamine-induced secretion of proopiomelanocortin-derived peptides and prolactin in rats.β-肾上腺素能受体参与组胺诱导的大鼠阿片促黑素皮质素原衍生肽和催乳素的分泌。
Eur J Endocrinol. 1995 Feb;132(2):223-8. doi: 10.1530/eje.0.1320223.

引用本文的文献

1
Restraint stress effects on glutamate signaling protein levels in the rats' frontal cortex: Does β1 adrenoceptor activity matter?束缚应激对大鼠额叶皮质中谷氨酸信号蛋白水平的影响：β1肾上腺素能受体活性起作用吗？
Front Pharmacol. 2025 Jan 6;15:1451895. doi: 10.3389/fphar.2024.1451895. eCollection 2024.
2
Glucocorticoid Excess in Patients with Pheochromocytoma Compared with Paraganglioma and Other Forms of Hypertension.皮质醇增多症患者与嗜铬细胞瘤和其他形式的高血压患者相比。
J Clin Endocrinol Metab. 2020 Sep 1;105(9):e3374-83. doi: 10.1210/clinem/dgaa423.
3
The use of α- or β-blockers to ameliorate the chronic stress of captivity in the house sparrow ().

本文引用的文献

1
Detectable amounts of adrenocorticotrophic hormone in blood following epinephrine.肾上腺素注射后血液中可检测到的促肾上腺皮质激素量。
Endocrinology. 1952 Feb;50(2):274-6. doi: 10.1210/endo-50-2-274.
2
Adenohypophysis and adrenal cortex.腺垂体和肾上腺皮质。
Annu Rev Physiol. 1960;22:579-614. doi: 10.1146/annurev.ph.22.030160.003051.
3
Blood ACTH: effects of ether, pentobarbital, epinephrine and pain.血液促肾上腺皮质激素：乙醚、戊巴比妥、肾上腺素及疼痛的影响。
使用α-或β-阻滞剂来改善家麻雀圈养的慢性应激（）。 （原文括号部分内容缺失，翻译仅针对现有完整部分）
Conserv Physiol. 2016 Oct 15;4(1):cow049. doi: 10.1093/conphys/cow049. eCollection 2016.
4
Circulatory catecholamines in the eel: origins and functions.鳗鱼循环中的儿茶酚胺：来源和功能。
Fish Physiol Biochem. 1989 Jun;7(1-6):273-8. doi: 10.1007/BF00004717.
5
Roles of the locus coeruleus and adrenergic receptors in brain-mediated hypothalamic-pituitary-adrenal axis responses to intracerebroventricular alcohol.蓝斑和肾上腺素能受体在中枢酒精诱导的下丘脑-垂体-肾上腺轴反应中的作用。
Alcohol Clin Exp Res. 2012 Jun;36(6):1084-90. doi: 10.1111/j.1530-0277.2011.01707.x. Epub 2012 Jan 11.
6
Hypothalamo-hypophyseal portal blood sampling from laboratory rats. The effects of endocrine manipulations on portal blood catecholamine concentrations.
Exp Brain Res. 1988;72(3):640-4. doi: 10.1007/BF00250608.
7
Stress induced ACTH release in capsaicin treated rats.辣椒素处理的大鼠中应激诱导的促肾上腺皮质激素释放
Br J Pharmacol. 1987 Apr;90(4):727-31. doi: 10.1111/j.1476-5381.1987.tb11226.x.
8
Effects of intravenous and intraventricular injection of antisera directed against corticotropin-releasing factor on the secretion of anterior pituitary hormones.静脉内和脑室内注射抗促肾上腺皮质激素释放因子抗血清对垂体前叶激素分泌的影响。
Proc Natl Acad Sci U S A. 1985 Nov;82(22):7787-90. doi: 10.1073/pnas.82.22.7787.
9
Ultrashort-loop positive feedback of corticotropin (ACTH)-releasing factor to enhance ACTH release in stress.促肾上腺皮质激素释放因子的超短环正反馈以增强应激时促肾上腺皮质激素的释放。
Proc Natl Acad Sci U S A. 1985 May;82(10):3528-31. doi: 10.1073/pnas.82.10.3528.
10
Interleukin 1 prevents loss of corticotropic responsiveness to beta-adrenergic stimulation in vitro.白细胞介素1可防止体外促肾上腺皮质激素对β-肾上腺素能刺激的反应性丧失。
Proc Natl Acad Sci U S A. 1988 Aug;85(15):5556-60. doi: 10.1073/pnas.85.15.5556.
Endocrinology. 1958 Dec;63(6):794-800. doi: 10.1210/endo-63-6-794.
4
Corticotropin-releasing factor (CRF)-like immunoreactivity in the vertebrate endocrine pancreas.脊椎动物内分泌胰腺中促肾上腺皮质激素释放因子（CRF）样免疫反应性
Proc Natl Acad Sci U S A. 1983 Mar;80(6):1721-5. doi: 10.1073/pnas.80.6.1721.
5
Activation of beta 2-adrenergic receptors on mouse anterior pituitary tumor cells increases cyclic adenosine 3':5'-monophosphate synthesis and adrenocorticotropin release.小鼠垂体前叶肿瘤细胞上β2-肾上腺素能受体的激活增加环磷酸腺苷的合成并促进促肾上腺皮质激素释放。
J Neurosci. 1983 Apr;3(4):725-32. doi: 10.1523/JNEUROSCI.03-04-00725.1983.
6
Characterization of beta-adrenergic receptors in rat brain and pituitary using a new high-affinity ligand, [125I]iodocyanopindolol.
Brain Res. 1983 Feb 21;261(2):249-59. doi: 10.1016/0006-8993(83)90628-5.
7
Desensitization of beta 2-adrenergic receptors and adrenocorticotropin release.
Biochem Biophys Res Commun. 1983 Feb 28;111(1):112-9. doi: 10.1016/s0006-291x(83)80124-7.
8
Role of vasopressin in the ACTH response to isoprenaline.血管加压素在促肾上腺皮质激素对异丙肾上腺素反应中的作用。
Eur J Pharmacol. 1982 Jul 30;81(4):645-54. doi: 10.1016/0014-2999(82)90354-5.
9
Corticotropin releasing factor stimulates adrenocorticotropin and beta-endorphin release from AtT-20 mouse pituitary tumor cells.促肾上腺皮质激素释放因子刺激AtT-20小鼠垂体瘤细胞释放促肾上腺皮质激素和β-内啡肽。
Biochem Biophys Res Commun. 1982 Jun 30;106(4):1364-71. doi: 10.1016/0006-291x(82)91264-5.
10
Stimulation of cyclic AMP accumulation and corticotropin release by synthetic ovine corticotropin-releasing factor in rat anterior pituitary cells: site of glucocorticoid action.合成的羊促肾上腺皮质激素释放因子对大鼠垂体前叶细胞中环磷酸腺苷积累和促肾上腺皮质激素释放的刺激作用：糖皮质激素的作用位点
Proc Natl Acad Sci U S A. 1982 Jun;79(11):3466-9. doi: 10.1073/pnas.79.11.3466.