环磷酸腺苷对突触形成的调节作用。
Modulation of synapse formation by cyclic adenosine monophosphate.
作者信息
Nirenberg M, Wilson S, Higashida H, Rotter A, Krueger K, Busis N, Ray R, Kenimer J G, Adler M
出版信息
Science. 1983 Nov 18;222(4625):794-9. doi: 10.1126/science.6314503.
Synapses between neuroblastoma-hybrid cells and myotubes exhibit a high degree of plasticity. Increase of cyclic adenosine monophosphate (AMP) levels of the hybrid cells for several days results in the appearance of functional voltage-sensitive Ca2+ channels, which are required for evoked secretion of acetylcholine. The results show that cyclic AMP regulates synaptogenesis by regulating the expression of voltage-sensitive Ca2+ channels, and suggest that cyclic AMP affects posttranslational modifications of some glycoproteins and cellular levels of certain proteins.
神经母细胞瘤杂交细胞与肌管之间的突触表现出高度的可塑性。将杂交细胞的环磷酸腺苷（AMP）水平提高数天会导致功能性电压敏感性Ca2+通道的出现，而诱发乙酰胆碱分泌需要这些通道。结果表明，环磷酸腺苷通过调节电压敏感性Ca2+通道的表达来调节突触形成，并提示环磷酸腺苷影响某些糖蛋白的翻译后修饰和某些蛋白质的细胞水平。
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