Turc-Carel C, Mugneret F, Sidaner I
Sem Hop. 1983 Sep 15;59(32):2267-72.
A review on the association between acute leukemias (AL) and constitutional chromosome abnormalities (CCA) is presented. AL, myeloblastic or lymphoblastic according to age are 18 to 20 times more frequent in Down Syndrome (DS) children than in non DS children. The incidence of acquired chromosome abnormalities is similar in leukemic cells of DS and non DS patients but the type of anomalies, in the leukemic myeloblastic cells of DS, are different : hyperdiploidy, excess of C, F and G. Gain of chromosomes 8, 19 and 22 would characterize leukemic myeloblasts in an early stage of differentiation. Recent data on transient leukemoid reactions show that a 21 in DS appears to be predisposing factor in the development of AL. Association between AL and other balanced or unbalanced CCA appears until now to be fortuitous.
本文对急性白血病（AL）与染色体结构异常（CCA）之间的关联进行了综述。根据年龄划分，唐氏综合征（DS）患儿中急性白血病（髓细胞性或淋巴细胞性）的发病率比非DS患儿高18至20倍。DS患者和非DS患者白血病细胞中获得性染色体异常的发生率相似，但DS患者白血病髓细胞中的异常类型不同：超二倍体、C、F和G组染色体过多。8号、19号和22号染色体的增加是白血病髓母细胞早期分化的特征。关于短暂性类白血病反应的最新数据表明，DS患者的21号染色体似乎是急性白血病发生的一个易感因素。到目前为止，急性白血病与其他平衡或不平衡的染色体结构异常之间的关联似乎是偶然的。
