Hählen K, Hagemeijer A
Tijdschr Kindergeneeskd. 1982 Dec;50(6):198-203.
In the last decade, specific chromosomal abnormalities were found in leukemic cells in children, which had diagnostic or even prognostic significance. Adult type chronic myeloid leukemia is associated with the Philadelphia chromosome (Ph1, t(9;22)), acute myeloid leukemia with maturation with t(8;21), acute promyelocytic leukemia with t(15;17), (myelo)-monocytic leukemia with abnormalities of chromosome II, and acute monoblastic leukemia with t(9;11). B-cell acute lymphocyte leukemias are associated with a t(8;14) or some other t(8q); in the other forms of acute lymphocytic leukemias a t(4;11) or 6q- is sometimes found. The presence of a t(8;21) seems to be associated with a better prognosis. In lymphocytic leukemias the presence of 50 or more chromosomes seems to predict a favourable prognosis, while, on the contrary, the presence of any translocation indicates a grave prognosis.
在过去十年中，在儿童白血病细胞中发现了特定的染色体异常，这些异常具有诊断甚至预后意义。成人型慢性髓细胞白血病与费城染色体（Ph1，t(9;22)）相关，急性髓细胞白血病伴成熟与t(8;21)相关，急性早幼粒细胞白血病与t(15;17)相关，（髓）单核细胞白血病与染色体11异常相关，急性单核细胞白血病与t(9;11)相关。B细胞急性淋巴细胞白血病与t(8;14)或其他一些t(8q)相关；在其他形式的急性淋巴细胞白血病中，有时会发现t(4;11)或6q-。t(8;21)的存在似乎与较好的预后相关。在淋巴细胞白血病中，50条或更多染色体的存在似乎预示着良好的预后，相反，任何易位的存在都表明预后不良。
