Lefaucheur C, Gueris J, Segrestaa J M, Warnet A
Sem Hop. 1983 Oct 6;59(35):2493-502.
Inhibin is a peptidic gonadal hormone which preferentially suppresses FSh secretion and synthesis. As its purification is not yet achieved, only bioassays are available, performed with testicular extracts or follicular fluid. Its secretion by granulosa cells and Sertoli cells is partly spontaneous, partly stimulated by androgens and FSH. In women, folliculogenesis is controlled by inhibin induced FSH fluctuations. But inhibin acts also at the gonadal level like the cybernis, peptidic substances secreted by the ovary, which modulate ovarian effects of gonadotrophins. Five of them have been identified : the oocyte maturation inhibitor, the luteinization inhibitor, the FSH binding inhibitor (implied in follicular atresia), the LH receptor binding inhibitor (involved in luteolysis), and gonadocrinins (which bind to ovarian LHRH-receptors). The discovery of these ovarian peptides leads to new concepts in folliculogenesis and luteolysis and may provide a new therapeutic approach in contraception and sterility fields.
抑制素是一种肽类性腺激素，它优先抑制促卵泡激素（FSH）的分泌和合成。由于其纯化尚未实现，目前仅可通过生物测定法进行检测，该方法使用睾丸提取物或卵泡液。颗粒细胞和支持细胞分泌抑制素，其分泌部分是自发的，部分受雄激素和促卵泡激素刺激。在女性中，卵泡发生受抑制素诱导的促卵泡激素波动控制。但抑制素在性腺水平上的作用类似于卵巢分泌的肽类物质——调控素，后者可调节促性腺激素对卵巢的作用。已鉴定出其中五种：卵母细胞成熟抑制剂、黄体化抑制剂、促卵泡激素结合抑制剂（与卵泡闭锁有关）、促黄体生成素受体结合抑制剂（参与黄体溶解）以及促性腺激素释放素（与卵巢促性腺激素释放激素受体结合）。这些卵巢肽的发现为卵泡发生和黄体溶解带来了新的概念，并可能为避孕和不育领域提供新的治疗方法。
