Hammond J M
Aust J Biol Sci. 1981;34(5-6):491-504. doi: 10.1071/bi9810491.
Data generated within the last several years have shown that follicular fluid contains substances, presumably peptide in nature, which exert potentially important effects on granulosa cells and the oocyte. This review briefly summarizes the current evidence concerning the nature and importance of these putative regulators including the luteinization inhibitor, oocyte maturation inhibitor, inhibitors of the binding of luteinizing hormone and follicle stimulating hormone, stimulators of ornithine decarboxylase and intrafollicular peptides with gonadotrophin-releasing activity. Although the existence of such activities has been clearly demonstrated, the evidence for a regulatory role of these agents in the control of ovarian physiology is not compelling. However, their occurrence must now be taken into account in our attempts to understand the mechanism of follicular growth, differentiation and atresia.
过去几年产生的数据表明，卵泡液含有一些物质，推测其本质为肽，这些物质对颗粒细胞和卵母细胞具有潜在的重要作用。本综述简要总结了有关这些假定调节因子的性质和重要性的当前证据，包括黄体化抑制剂、卵母细胞成熟抑制剂、促黄体生成素和促卵泡激素结合抑制剂、鸟氨酸脱羧酶刺激剂以及具有促性腺激素释放活性的卵泡内肽。尽管这些活性的存在已得到明确证实，但这些因子在卵巢生理控制中起调节作用的证据并不确凿。然而，在我们试图理解卵泡生长、分化和闭锁机制时，现在必须考虑到它们的存在。
