Dubuc P U, Willis P L
Diabetologia. 1978 Feb;14(2):129-33. doi: 10.1007/BF01263451.
The effects of daily oxytetracycline injections on the metabolism and growth of prepubertal, 10 and 24-week old ob/ob and lean mice were examined. Drug treatment (100 mg/kg) between 17 and 28 days of age similarly reduced body weight gain and skeletal growth of both ob/ob and lean mice, but had little effect on obesity, serum glucose, or IRI levels. In older obese mice, 6 days of oxytetracycline led to substantial reductions of serum glucose, serum IRI, and obesity when compared with either ad libitum fed obese mice or food-restricted ob/ob mice serving as weight loss controls. In lean mice oxytetracycline also significantly reduced body weight and serum glucose, while no effects on obesity or IRI levels were noted. The present data show that oxytetracycline reduces the severity of many of the diabetic symptoms of ob/ob mice, but that only the ameliorative effects on obesity and hyperinsulinaemia appear to be specific to the ob/ob genotype.
研究了每日注射土霉素对青春期前10周龄和24周龄的肥胖（ob/ob）小鼠和瘦型小鼠的代谢及生长的影响。在17至28日龄期间进行药物治疗（100mg/kg），同样降低了ob/ob小鼠和瘦型小鼠的体重增加及骨骼生长，但对肥胖、血糖或胰岛素释放指数（IRI）水平影响较小。与自由进食的肥胖小鼠或作为体重减轻对照的限食ob/ob小鼠相比，在年龄较大的肥胖小鼠中，6天的土霉素治疗导致血糖、血清IRI及肥胖程度大幅降低。在瘦型小鼠中，土霉素也显著降低了体重和血糖，而未观察到对肥胖或IRI水平的影响。目前的数据表明，土霉素可减轻ob/ob小鼠许多糖尿病症状的严重程度，但只有对肥胖和高胰岛素血症的改善作用似乎是ob/ob基因型所特有的。
