土霉素对肥胖小鼠胰岛素抵抗的影响。
The effect of oxytetracycline on insulin resistance in obese mice.
作者信息
Bégin-Heck N, Bourassa M, Heick H M
出版信息
Biochem J. 1974 Sep;142(3):465-75. doi: 10.1042/bj1420465.
Abstract
- Chronic oxytetracycline treatment was found to improve the insulin resistance of the obese-hyperglycaemic mouse. 2. The improved response to insulin was accompanied by decreased concentrations of circulating insulin and glucose, by a decrease in the lipid content of the liver and by an increase in the insulin-receptor sites of the liver and adipose tissue. 3. The increase in insulin-receptor sites preceded the fall in blood glucose. 4. Comparable studies done on food-restricted animals indicated that although chronic food restriction corrected the hyperinsulinaemia it did not restore the insulin-receptor sites or the hyperglycaemia.
摘要
- 研究发现，长期使用土霉素治疗可改善肥胖型高血糖小鼠的胰岛素抵抗。2. 对胰岛素反应的改善伴随着循环胰岛素和葡萄糖浓度的降低、肝脏脂质含量的减少以及肝脏和脂肪组织中胰岛素受体位点的增加。3. 胰岛素受体位点的增加先于血糖的下降。4. 对食物受限动物进行的类似研究表明，尽管长期食物限制可纠正高胰岛素血症，但并不能恢复胰岛素受体位点或高血糖症。
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