膳食抗氧化剂对大鼠肝脏微粒体中苯并[a]芘代谢的影响。
Effect of dietary antioxidants on benzo[a]pyrene metabolism in rat liver microsomes.
作者信息
Kahl R, Kahl G F
出版信息
Toxicology. 1983;28(3):229-33. doi: 10.1016/0300-483x(83)90120-8.
PMID:6314610
Abstract
Feeding of rats with 1% ethoxyquin (EQ) and butylated hydroxytoluene (BHT) but not butylated hydroxyanisole (BHA) increases the formation rate of benzo[a]pyrene (BP)-4,5-dihydrodiol from BP in hepatic microsomes. The production of other BP-dihydrodiols and of BP phenols is decreased after treatment with EQ, BHT and BHA. EQ and BHT are more effective than BHA in inducing epoxide hydrolase (EH) activity towards styrene oxide as the substrate.
摘要
用1%的乙氧喹（EQ）和丁基羟基甲苯（BHT）而非丁基羟基茴香醚（BHA）喂养大鼠，会提高肝微粒体中苯并[a]芘（BP）向BP - 4,5 - 二氢二醇的转化速率。用EQ、BHT和BHA处理后，其他BP - 二氢二醇和BP - 酚的生成量减少。以氧化苯乙烯为底物时，EQ和BHT在诱导环氧水解酶（EH）活性方面比BHA更有效。
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