疾病控制中心军团菌抗原和抗体血清学检测的现状

Status of serologic tests for Legionella antigen and antibody at the Centers for Disease Control.

作者信息

Wilkinson H W

出版信息

Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1983 Jul;255(1):3-7.

Abstract

Nine species and 16 serogroups have been defined for the genus Legionella. Direct immunofluorescence assay (DFA) results with 12 conjugates in 3 polyvalent pools showed that L. pneumophila serogroup 1 comprised 63% of the legionellae identified in specimens from patients with legionellosis. Indirect immunofluorescence assay (IFA) titers of paired sera from patients with suspected legionellosis against multiple Legionella antigens showed preferential reactivity for the L. pneumophila antigens. The multiple-antigen IFA was 96% specific when sera from patients with disease due to other etiologic agents were tested. The prevalence of antibody among well individuals is relatively high in some population groups.

摘要

嗜肺军团菌属已确定有9个种和16个血清群。用3个多价组合中的12种结合物进行直接免疫荧光测定（DFA）结果显示，嗜肺军团菌血清1型占军团菌病患者标本中鉴定出的军团菌的63%。疑似军团菌病患者的配对血清针对多种嗜肺军团菌抗原的间接免疫荧光测定（IFA）滴度显示，对嗜肺军团菌抗原具有优先反应性。当检测其他病原体所致疾病患者的血清时，多抗原IFA的特异性为96%。在一些人群中，健康个体的抗体流行率相对较高。