Rasmussen A B, Pedersen E B, Rømer F K, Johannesen P, Kristensen S, Lauritsen J G, Wohlert M
Acta Obstet Gynecol Scand. 1983;62(4):341-4. doi: 10.3109/00016348309156235.
Serum angiotensin-converting enzyme (SACE) levels were determined in normotensive pregnant subjects and patients with pre-eclampsia in the third trimester of pregnancy and 5 days, 3 and 6 months after parturition, and also in the first and second trimester in the normotensive group. SACE levels were reduced during pregnancy and 5 days after delivery in the normotensive subjects compared with the levels 3 and 6 months after delivery and to the non-pregnant control subjects. After correction for plasma volume expansion, SACE was reduced in first and second trimester only. In pre-eclampsia both SACE and corrected SACE were significantly lower in third trimester and 5 days after parturition than 3 and 6 months after delivery and in non-pregnant control subjects. The reason for the reduced level of SACE in first and second trimester during normal pregnancy is not known. The low SACE levels in pre-eclampsia may be a secondary phenomenon due to a decreased placental synthesis without primary importance for the blood pressure regulation.
测定了血压正常的孕妇以及子痫前期患者在妊娠晚期、产后5天、3个月和6个月时的血清血管紧张素转换酶（SACE）水平，同时也测定了血压正常组在妊娠早期和中期的SACE水平。与产后3个月和6个月时以及非妊娠对照组相比，血压正常的受试者在孕期及产后5天时SACE水平降低。在校正血容量扩张后，仅在妊娠早期和中期SACE水平降低。子痫前期患者在妊娠晚期及产后5天时的SACE和校正后的SACE均显著低于产后3个月和6个月时以及非妊娠对照组。正常妊娠时妊娠早期和中期SACE水平降低的原因尚不清楚。子痫前期患者SACE水平低可能是由于胎盘合成减少导致的继发性现象，对血压调节无主要影响。
