Sakazaki S, Umeyama K, Nakagawa H, Hashimoto H, Kamino K, Mitsuhashi T, Yamaguchi K
Am J Surg. 1983 Nov;146(5):674-9. doi: 10.1016/0002-9610(83)90310-0.
A 66 year old woman was admitted for right hypochondriac pain and an abdominal tumor. A tumor of the pancreatic head with duodenal infiltration and liver metastases was found by laparotomy, and pancreaticoduodenectomy was performed. In addition, there was associated cholelithiasis and a goiter. Histopathologically, a tumor of the islets of Langerhans was suspected. The tumor tissue was positive by the Hellman-Hellerström silver impregnation method, and electron microscopy confirmed the presence of secretory granules similar to D cells. The tumor tissue contained a large quantity of somatostatin (1.3 micrograms/g). Finally, the diagnosis of somatostatin-producing tumor originating in the pancreas was made.
一名66岁女性因右季肋部疼痛和腹部肿瘤入院。剖腹手术发现胰头肿瘤伴十二指肠浸润及肝转移，遂行胰十二指肠切除术。此外，还伴有胆结石和甲状腺肿。组织病理学检查怀疑为朗格汉斯胰岛肿瘤。肿瘤组织经赫尔曼-赫勒斯特伦银浸染法检测呈阳性，电子显微镜检查证实存在类似于D细胞的分泌颗粒。肿瘤组织含有大量生长抑素（1.3微克/克）。最终确诊为起源于胰腺的生长抑素分泌肿瘤。
