Halperin S A, Eggleston P A, Hendley J O, Suratt P M, Gröschel D H, Gwaltney J M
Am Rev Respir Dis. 1983 Nov;128(5):806-10. doi: 10.1164/arrd.1983.128.5.806.
To investigate the pathogenesis of lower respiratory tract symptoms during rhinovirus infection, 19 healthy young adult volunteers were exposed to a currently unnumbered rhinovirus strain (HH). Spirometry and bronchoprovocation with histamine sulfate were performed prior to and on Days 4, 5, and 21 after exposure to the virus. Fiberoptic bronchoscopy for visualization and culture of the tracheobronchial mucosa was done on Day 4 or Day 5. Fourteen of 19 volunteers were infected with rhinovirus; 9 of the 14 had clinical illness. Rhinovirus was isolated from the bronchial brush specimens in 5 of the 13 infected volunteers bronchoscoped, all of whom had clinical illness. Rhinovirus was not isolated at bronchoscopy from any of the 5 infected volunteers without clinical illness (p = 0.025, Fisher's exact test). Spirometry and histamine bronchoprovocation were unchanged during experimental rhinovirus infection. Rhinovirus may invade the lower respiratory tract in symptomatic infections, and thereby cause lower respiratory tract symptoms.
为研究鼻病毒感染期间下呼吸道症状的发病机制，19名健康的年轻成年志愿者暴露于一种目前未编号的鼻病毒株（HH）。在接触病毒之前以及接触后的第4天、第5天和第21天进行了肺活量测定和硫酸组胺支气管激发试验。在第4天或第5天进行了纤维支气管镜检查，以观察气管支气管黏膜并进行培养。19名志愿者中有14人感染了鼻病毒；14人中有9人出现临床疾病。在接受支气管镜检查的13名感染志愿者中，有5人的支气管刷检标本中分离出鼻病毒，所有这些人都有临床疾病。在5名没有临床疾病的感染志愿者中，支气管镜检查均未分离出鼻病毒（p = 0.025，Fisher精确检验）。在实验性鼻病毒感染期间，肺活量测定和组胺支气管激发试验没有变化。鼻病毒可能在有症状的感染中侵入下呼吸道，从而引起下呼吸道症状。
